COLEC11

Chr 2p25.3

collectin subfamily member 11

Aliases:: MGC3279, CL-K1, CL-11
MANE:: ENST00000349077.9

OMIM: 612502 ↗NCBI: 78989 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

COLEC11 · Q9BWP8

v62025-08-01

Predicted Aligned Error matrix for COLEC11 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.3/ 100

Confident

271 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)8%
Low(50–70)26%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Rare syndromic craniosynostosis or isolated multisuture synostosis
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
Unknown
Primary immunodeficiency or monogenic inflammatory bowel disease

Disease associations (Open Targets)

3MC syndrome 2
0.79
3MC syndrome
0.71
Abnormality of the skeletal system
0.57
hereditary disease
0.41
metabolic syndrome
0.36
metabolic dysfunction-associated steatotic liver disease
0.36
cervical carcinoma
0.24
Abnormal nasolacrimal system morphology
0.23
Chorioretinal scar
0.22
kidney transplant
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Collectin-11

Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:21258343, PubMed:23954398, PubMed:25912189). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481)