coat protein complex I subunit alpha
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Diagnostic Grade (Green)
Autoinflammatory disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood interstitial lung disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCOVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownPrimary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownautoimmune interstitial lung disease-arthritis syndrome
interstitial lung disease
Alzheimer disease
neurodegenerative disease
Parkinson disease
multiple sclerosis
lysosomal storage disease
hereditary disease
autosomal dominant Alport syndrome
Systemic autoinflammation
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Coatomer subunit alpha
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)
COPA · P53621
Mean pLDDT
83.1/ 100
Confident
1,224 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
