AlphaFold predicted structure
CORO1A · P31146
Mean pLDDT
93.1/ 100
Very high
461 residues
Confidence breakdown
- Very high(≥ 90)86%
- Confident(70–90)9%
- Low(50–70)2%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CORO1A
Chr 16p11.2coronin 1A
- Aliases:
- HCORO1, p57, coronin-1
- MANE:
- ENST00000219150.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalEpidermodysplasia verruciformis
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
severe combined immunodeficiency due to CORO1A deficiency
0.76severe combined immunodeficiency
0.53neurodegenerative disease
0.49combined immunodeficiency
0.46Omenn syndrome
0.46tuberculosis
0.38sinoatrial node disorder
0.26hereditary disease
0.19autism spectrum disorder
0.14sign or symptom
0.10
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Coronin-1A
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes
Diseases associated with CORO1A
Curated MONDO disease pages that list CORO1A among their top associated genes.