CPA1

Chr 7q32.2

carboxypeptidase A1

MANE:: ENST00000011292.8

OMIM: 114850 ↗NCBI: 1357 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CPA1 · P15085

v62025-08-01

Predicted Aligned Error matrix for CPA1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

95.2/ 100

Very high

419 residues

Confidence breakdown

Very high(≥ 90)93%
Confident(70–90)3%
Low(50–70)1%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Pancreatitis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

type 2 diabetes mellitus
0.47
neurodegenerative disease
0.45
hereditary chronic pancreatitis
0.40
Increased blood pressure
0.32
chronic pancreatitis
0.20
infection
0.08
type 1 diabetes mellitus
0.07
Hyperlipoproteinemia type 1
0.06
cancer
0.06
Partial pancreatic agenesis
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Carboxypeptidase A1

Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:20385563, PubMed:8806703). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity)