CRADD

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

• Malformations of cortical development

  BIALLELIC, autosomal or pseudoautosomal

• DDG2P

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• autosomal recessive non-syndromic intellectual disability

  0.61

• intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly

  0.46

• Intellectual disability

  0.46

• osteoarthritis

  0.45

• osteoarthritis, knee

  0.43

• atrial fibrillation

  0.40

• osteoarthritis, hip

  0.39

• syndromic intellectual disability

  0.37

• familial isolated arrhythmogenic right ventricular dysplasia

  0.34

• arthropathy

  0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)