CRMP1

Chr 4p16.2

collapsin response mediator protein 1

Aliases:: DRP-1, DPYSL1
MANE:: ENST00000324989.12

OMIM: 602462 ↗NCBI: 1400 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CRMP1 · Q14194

v62025-08-01

Predicted Aligned Error matrix for CRMP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.3/ 100

Very high

572 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)4%
Low(50–70)6%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodegenerative disease
0.34
alcohol drinking
0.29
stroke disorder
0.29
acute tonsillitis
0.24
pituitary gland disorder
0.23
neurodevelopmental disorder
0.22
Intellectual disability
0.19
placental retention
0.10
musculoskeletal system disorder
0.09
shoulder fracture
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dihydropyrimidinase-related protein 1

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413)