CRYGD

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bilateral congenital or childhood onset cataracts

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Structural eye disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

• Cataract-microcornea syndrome

  0.69

• cataract

  0.61

• early-onset nuclear cataract

  0.59

• pulverulent cataract

  0.59

• Aculeiform cataract

  0.53

• early-onset non-syndromic cataract

  0.51

• early-onset zonular cataract

  0.51

• Autosomal dominant optic atrophy and cataract

  0.48

• autosomal dominant cataract

  0.46

• Developmental cataract

  0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with CRYGD

Curated MONDO disease pages that list CRYGD among their top associated genes.

• cataractRare
• early-onset zonular cataractRare