AlphaFold predicted structure
CSF2RB · P32927
Mean pLDDT
64.0/ 100
Low
897 residues
Confidence breakdown
- Very high(≥ 90)35%
- Confident(70–90)14%
- Low(50–70)4%
- Very low(< 50)46%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
CSF2RB
Chr 22q12.3colony stimulating factor 2 receptor subunit beta
- Aliases:
- IL5RB, CD131, betaGMR
- MANE:
- ENST00000403662.8
Annotations refreshed 11 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Childhood interstitial lung disease
BIALLELIC, autosomal or pseudoautosomalCOVID-19 research
BIALLELIC, autosomal or pseudoautosomalFamilial pulmonary fibrosis
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalPulmonary fibrosis familial
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Congenital pulmonary alveolar proteinosis
0.75Intraalveolar phospholipid accumulation
0.58acute myeloid leukemia
0.52neurodegenerative disease
0.46Crohn disease
0.45autoimmune pulmonary alveolar proteinosis
0.42neoplasm
0.41atopic eczema
0.41pulmonary alveolar proteinosis
0.40dermatitis
0.39
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cytokine receptor common subunit beta
Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)
Diseases associated with CSF2RB
Curated MONDO disease pages that list CSF2RB among their top associated genes.