CSNK2B

Chr 6p21.33

casein kinase 2 beta

Aliases:: Ckb1, Ckb2
MANE:: ENST00000375882.7

OMIM: 115441 ↗NCBI: 1460 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CSNK2B · P67870

v62025-08-01

Predicted Aligned Error matrix for CSNK2B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

93.6/ 100

Very high

215 residues

Confidence breakdown

Very high(≥ 90)87%
Confident(70–90)7%
Low(50–70)6%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Poirier-Bienvenu neurodevelopmental syndrome
0.78
neurodegenerative disease
0.55
hereditary disease
0.54
autosomal dominant non-syndromic intellectual disability
0.44
neurodevelopmental disorder
0.43
Intellectual disability
0.37
autoimmune disorder of central nervous system
0.37
Alzheimer disease
0.34
Parkinson disease
0.34
multiple sclerosis
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Casein kinase II subunit beta

Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity)