CSTF2

Chr Xq22.1

cleavage stimulation factor subunit 2

Aliases:: CstF-64
MANE:: ENST00000372972.7

OMIM: 300907 ↗NCBI: 1478 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CSTF2 · P33240

v62025-08-01

Predicted Aligned Error matrix for CSTF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.8/ 100

Low

577 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)23%
Low(50–70)20%
Very low(< 50)46%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

dengue disease
0.37
intellectual developmental disorder, X-linked 113
0.36
Intellectual disability
0.19
hepatocellular carcinoma
0.11
cancer
0.09
neoplasm
0.09
gastric cancer
0.07
lung cancer
0.03
lung carcinoma
0.03
laryngotracheoesophageal cleft
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cleavage stimulation factor subunit 2

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs