CTNNA1

Chr 5q31.2

catenin alpha 1

Aliases:: CAP102
MANE:: ENST00000302763.12

OMIM: 116805 ↗NCBI: 1495 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CTNNA1 · P35221

v62025-08-01

Predicted Aligned Error matrix for CTNNA1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.9/ 100

Confident

906 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)28%
Low(50–70)6%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hereditary diffuse gastric cancer
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Rare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Butterfly-shaped pigment dystrophy
0.75
Inherited cancer-predisposing syndrome
0.56
hereditary neoplastic syndrome
0.56
hereditary diffuse gastric adenocarcinoma
0.55
colorectal cancer
0.51
Familial exudative vitreoretinopathy
0.39
patterned macular dystrophy 1
0.39
exudative vitreoretinopathy
0.38
hereditary mixed polyposis syndrome
0.37
Retinal dystrophy
0.35

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Catenin alpha-1

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties (PubMed:40983751). Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation