CTNNA2

Chr 2p12

catenin alpha 2

Aliases:: CAP-R, CT114
MANE:: ENST00000402739.9

OMIM: 114025 ↗NCBI: 1496 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

CTNNA2 · P26232

v62025-08-01

Predicted Aligned Error matrix for CTNNA2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.5/ 100

Confident

953 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)27%
Low(50–70)6%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

complex cortical dysplasia with other brain malformations
0.72
Hereditary breast and ovarian cancer syndrome
0.34
hereditary breast ovarian cancer syndrome
0.34
lung adenocarcinoma
0.33
diabetes mellitus
0.32
knee fracture
0.32
prostate adenocarcinoma
0.31
Abnormality of refraction
0.30
staphylococcus aureus infection
0.30
type 1 diabetes mellitus
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Catenin alpha-2

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity)