CTRC

Chr 1p36.21

chymotrypsin C

Aliases:: CLCR, ELA4
MANE:: ENST00000375949.5

OMIM: 601405 ↗NCBI: 11330 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CTRC · Q99895

v62025-08-01

Predicted Aligned Error matrix for CTRC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

93.5/ 100

Very high

268 residues

Confidence breakdown

Very high(≥ 90)91%
Confident(70–90)2%
Low(50–70)5%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Pancreatitis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

hereditary chronic pancreatitis
0.76
chronic pancreatitis
0.75
alcoholic pancreatitis
0.42
acute pancreatitis
0.35
non-alcoholic pancreatitis
0.35
Syndactyly type 2
0.06
retinitis pigmentosa
0.06
Hirschsprung disease-type D brachydactyly syndrome
0.06
Hirschsprung disease - type D brachydactyly
0.06
metaphyseal anadysplasia
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Chymotrypsin-C

Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity