CTU2

Chr 16q24.3

cytosolic thiouridylase subunit 2

Aliases:: NCS2
MANE:: ENST00000453996.7

OMIM: 617057 ↗NCBI: 348180 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CTU2 · Q2VPK5

v62025-08-01

Predicted Aligned Error matrix for CTU2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.4/ 100

Confident

515 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)18%
Low(50–70)7%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

CAKUT
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Differences in sex development
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome
0.75
Varicose veins
0.41
microcephaly
0.34
osteoarthritis, knee
0.32
congenital anomaly of kidney and urinary tract
0.29
vein disorder
0.28
osteoarthritis, hip
0.26
lymphatic system disorder
0.24
cardiovascular disorder
0.21
osteoarthritis
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cytoplasmic tRNA 2-thiolation protein 2

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position