CXADR

Chr 21q21.1

CXADR cell adhesion molecule

Aliases:: CAR
MANE:: ENST00000284878.12

OMIM: 602621 ↗NCBI: 1525 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CXADR · P78310

v62025-08-01

Predicted Aligned Error matrix for CXADR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.3/ 100

Confident

365 residues

Confidence breakdown

Very high(≥ 90)58%
Confident(70–90)10%
Low(50–70)14%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.37
Abnormality of the skeletal system
0.34
atrial fibrillation
0.33
osteoarthritis
0.32
gastroesophageal reflux disease
0.32
osteoarthritis, knee
0.31
Age-related cataract
0.30
osteoarthritis, hip
0.30
placenta praevia
0.29
hypertensive disorder
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Coxsackievirus and adenovirus receptor

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair