AlphaFold predicted structure
CXCL8 · P10145
Mean pLDDT
88.1/ 100
Confident
99 residues
Confidence breakdown
- Very high(≥ 90)65%
- Confident(70–90)21%
- Low(50–70)14%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CXCL8
Chr 4q13.3C-X-C motif chemokine ligand 8
- Aliases:
- SCYB8, LUCT, LECT, MDNCF, TSG-1
- MANE:
- ENST00000307407.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
UnknownFamilial Meniere Disease
Pancreatitis
Disease associations (Open Targets)
coronary artery disorder
0.35myocardial infarction
0.35ischemic stroke
0.34placenta praevia
0.21endocrine system disorder
0.19hepatocellular carcinoma
0.14melanoma
0.14contact dermatitis
0.14chronic obstructive pulmonary disease
0.14non-small cell lung carcinoma
0.13
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-8
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activation (PubMed:2145175, PubMed:9623510). Released in response to an inflammatory stimulus, exerts its effect by binding to the G protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:1840701, PubMed:1891716). G protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:11971003, PubMed:8662698)
Diseases associated with CXCL8
Curated MONDO disease pages that list CXCL8 among their top associated genes.