CXCR2

Chr 2q35

C-X-C motif chemokine receptor 2

Aliases:: CMKAR2, CD182
MANE:: ENST00000318507.7

OMIM: 146928 ↗NCBI: 3579 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CXCR2 · P25025

v62025-08-01

Predicted Aligned Error matrix for CXCR2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.6/ 100

Confident

360 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)42%
Low(50–70)13%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ulcerative colitis
0.52
WHIM syndrome 2
0.50
inflammatory bowel disease
0.44
psoriasis
0.35
Crohn disease
0.34
sclerosing cholangitis
0.33
ankylosing spondylitis
0.33
type 1 diabetes mellitus
0.30
COVID-19
0.15
breast cancer
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

C-X-C chemokine receptor type 2

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (PubMed:1891716). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site