CXCR3

Chr Xq13.1

C-X-C motif chemokine receptor 3

Aliases:: CKR-L2, CMKAR3, IP10-R, MigR, CD183
MANE:: ENST00000373693.4

OMIM: 300574 ↗NCBI: 2833 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CXCR3 · P49682

v62025-08-01

Predicted Aligned Error matrix for CXCR3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.6/ 100

Confident

368 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)31%
Low(50–70)10%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

neoplasm
0.12
infection
0.12
systemic sclerosis
0.11
rheumatoid arthritis
0.11
breast cancer
0.11
melanoma
0.11
COVID-19
0.11
myeloid sarcoma
0.11
breast carcinoma
0.11
type 1 diabetes mellitus
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

C-X-C chemokine receptor type 3

Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling