AlphaFold predicted structure
CYCS · P99999
Mean pLDDT
97.9/ 100
Very high
105 residues
Confidence breakdown
- Very high(≥ 90)98%
- Confident(70–90)2%
- Low(50–70)0%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CYCS
Chr 7p15.3cytochrome c, somatic
- Aliases:
- HCS, CYC
- MANE:
- ENST00000305786.7
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownLikely inborn error of metabolism
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMitochondrial disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPossible mitochondrial disorder - nuclear genes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood onset dystonia, chorea or related movement disorder
Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
thrombocytopenia 4
0.75Thrombocytopenia
0.65neurodegenerative disease
0.56hereditary thrombocytopenia with normal platelets
0.56autosomal thrombocytopenia with normal platelets
0.37Abnormal bleeding
0.26cancer
0.10hepatocellular carcinoma
0.08ischemia
0.08esophageal disorder
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cytochrome c
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain