CYS1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Cystic kidney disease

  BIALLELIC, autosomal or pseudoautosomal

• Renal ciliopathies

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• atrial fibrillation

  0.37

• autosomal recessive polycystic kidney disease

  0.36

• neurodegenerative disease

  0.35

• polyarteritis nodosa

  0.32

• gout

  0.30

• polycystic kidney disease

  0.23

• duodenal ulcer

  0.18

• polycystic liver disease 3 with or without kidney cysts

  0.10

• polycystic liver disease 4 with or without kidney cysts

  0.10

• renal cysts and diabetes syndrome

  0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.