DAAM2

Chr 6p21.2

dishevelled associated activator of morphogenesis 2

Aliases:: KIAA0381, NPHS24
MANE:: ENST00000274867.9

OMIM: 606627 ↗NCBI: 23500 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DAAM2 · Q86T65

v62025-08-01

Predicted Aligned Error matrix for DAAM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.5/ 100

Confident

1,068 residues

Confidence breakdown

Very high(≥ 90)42%
Confident(70–90)35%
Low(50–70)9%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

nephrotic syndrome, type 24
0.52
Abnormality of the skeletal system
0.43
steroid-resistant nephrotic syndrome
0.37
familial idiopathic steroid-resistant nephrotic syndrome
0.37
alcohol drinking
0.32
nervous system benign neoplasm
0.31
adolescent idiopathic scoliosis
0.30
aortic atherosclerosis
0.29
Umbilical hernia
0.28
type 2 diabetes mellitus
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Disheveled-associated activator of morphogenesis 2

Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (PubMed:33232676)