DACH2

Chr Xq21.2

dachshund family transcription factor 2

MANE:: ENST00000373125.9

OMIM: 300608 ↗NCBI: 117154 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DACH2 · Q96NX9

v62025-08-01

Predicted Aligned Error matrix for DACH2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

61.4/ 100

Low

599 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)7%
Low(50–70)11%
Very low(< 50)52%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary ovarian insufficiency
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Disease associations (Open Targets)

COVID-19
0.26
severe acute respiratory syndrome
0.26
prostate cancer
0.19
premature menopause
0.19
Premature ovarian insufficiency
0.18
Meckel syndrome
0.05
Matthew-Wood syndrome
0.05
hereditary spherocytosis
0.04
Fraser syndrome
0.04
sickle cell disease
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dachshund homolog 2

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression also seems to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain