DALRD3

Chr 3p21.31

DALR anticodon binding domain containing 3

Aliases:: FLJ10496
MANE:: ENST00000341949.9

OMIM: 618904 ↗NCBI: 55152 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DALRD3 · Q5D0E6

v62025-08-01

Predicted Aligned Error matrix for DALRD3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.9/ 100

Confident

543 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)25%
Low(50–70)8%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

developmental and epileptic encephalopathy, 86
0.44
mitochondrial complex I deficiency, nuclear type 18
0.43
mitochondrial complex I deficiency
0.43
neurodegenerative disease
0.40
undetermined early-onset epileptic encephalopathy
0.37
mitochondrial complex I deficiency, nuclear type 1
0.19
hereditary disease
0.17
smoking cessation
0.05
metabolic syndrome
0.05
atrial fibrillation
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DALR anticodon-binding domain-containing protein 3

Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B