DAND5

Chr 19p13.13

DAN domain BMP antagonist family member 5

Aliases:: FLJ38607, CKTSF1B3, DANTE, GREM3, CER2
MANE:: ENST00000317060.4

OMIM: 609068 ↗NCBI: 199699 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DAND5 · Q8N907

v62025-08-01

Predicted Aligned Error matrix for DAND5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.3/ 100

Low

189 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)16%
Low(50–70)20%
Very low(< 50)31%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

heterotaxy, visceral, 13, autosomal
0.38
Heterotaxy
0.29
breast cancer
0.08
Heterotaxia
0.06
breast carcinoma
0.06
atrial septal defect
0.06
atrial septal defect 1
0.06
Congenitally uncorrected transposition of the great arteries
0.05
ciliary dyskinesia, primary, 52
0.05
heterotaxy, visceral, 12, autosomal
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DAN domain family member 5

Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance (PubMed:33587337)