DAP3

Chr 1q22

death associated protein 3

Aliases:: MRPS29, DAP-3, MRP-S29, bMRP-10, MGC126058
MANE:: ENST00000368336.10

OMIM: 602074 ↗NCBI: 7818 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DAP3 · P51398

v62025-08-01

Predicted Aligned Error matrix for DAP3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.0/ 100

Confident

398 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)19%
Low(50–70)1%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Deafness and congenital structural abnormalities
BIALLELIC, autosomal or pseudoautosomal
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Perrault syndrome 7
0.60
neurodegenerative disease
0.49
grange syndrome
0.35
Perrault syndrome 1
0.34
psoriasis
0.28
prostate carcinoma
0.26
idiopathic pulmonary fibrosis
0.24
hereditary disease
0.19
atrial fibrillation
0.17
hepatocellular carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Small ribosomal subunit protein mS29

As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103)