DAW1

Chr 2q36.3

dynein assembly factor with WD repeats 1

Aliases:: FLJ25955, ODA16, DNAAF18
MANE:: ENST00000309931.3

OMIM: 620279 ↗NCBI: 164781 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DAW1 · Q8N136

v62025-08-01

Predicted Aligned Error matrix for DAW1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

96.6/ 100

Very high

415 residues

Confidence breakdown

Very high(≥ 90)97%
Confident(70–90)2%
Low(50–70)1%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism
BIALLELIC, autosomal or pseudoautosomal
Non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 52
0.67
primary ciliary dyskinesia
0.59
dementia
0.38
allergic rhinitis
0.38
asthma
0.35
allergic disease
0.34
Eczematoid dermatitis
0.33
ovarian neoplasm
0.28
childhood onset asthma
0.27
adolescent idiopathic scoliosis
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dynein assembly factor with WD repeat domains 1

Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis (PubMed:36074124). Facilitates the onset of robust cilia motility during development (PubMed:36074124)