DCN

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Corneal abnormalities

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Corneal dystrophy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Structural eye disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• congenital stromal corneal dystrophy

  0.70

• lagophthalmos

  0.30

• glaucoma

  0.26

• open-angle glaucoma

  0.26

• diabetes mellitus

  0.25

• type 2 diabetes mellitus

  0.25

• myopia

  0.25

• systemic lupus erythematosus

  0.22

• preeclampsia

  0.22

• lens disorder

  0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)