AlphaFold predicted structure
DCPS · Q96C86
Mean pLDDT
88.4/ 100
Confident
337 residues
Confidence breakdown
- Very high(≥ 90)77%
- Confident(70–90)11%
- Low(50–70)1%
- Very low(< 50)10%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DCPS
Chr 11q24.2decapping enzyme, scavenger
- Aliases:
- HSPC015, HINT-5, HSL1, HINT5, DCS-1
- MANE:
- ENST00000263579.5
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
autosomal recessive non-syndromic intellectual disability
0.67neurodegenerative disease
0.57autoimmune disorder of central nervous system
0.43response to statin
0.26urinary system disorder
0.22hereditary disease
0.19Romano-Ward syndrome
0.09familial long QT syndrome
0.09coronary atherosclerosis
0.08Familial short QT syndrome
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
m7GpppX diphosphatase
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death
Diseases associated with DCPS
Curated MONDO disease pages that list DCPS among their top associated genes.