AlphaFold predicted structure
DCT · P40126
Mean pLDDT
89.1/ 100
Confident
519 residues
Confidence breakdown
- Very high(≥ 90)81%
- Confident(70–90)7%
- Low(50–70)3%
- Very low(< 50)9%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
DCT
Chr 13q32.1dopachrome tautomerase
- Aliases:
- TRP-2, TRP2
- MANE:
- ENST00000377028.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Albinism or congenital nystagmus
BIALLELIC, autosomal or pseudoautosomalRetinal disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
oculocutaneous albinism type 8
0.75hair color
0.42albinism
0.36age related macular degeneration 7
0.33alcohol drinking
0.30Vertigo
0.29Pancreatic pseudocyst
0.29Abnormality of skin pigmentation
0.26suntan
0.25hereditary disease
0.19
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
L-dopachrome tautomerase
Plays a role in melanin biosynthesis (PubMed:33100333). Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)