AlphaFold predicted structure
DDOST · P39656
Mean pLDDT
89.2/ 100
Confident
456 residues
Confidence breakdown
- Very high(≥ 90)84%
- Confident(70–90)6%
- Low(50–70)1%
- Very low(< 50)9%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DDOST
Chr 1p36.12dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
- Aliases:
- OST, KIAA0115, OST48, WBP1
- MANE:
- ENST00000602624.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Congenital disorders of glycosylation
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
DDOST-congenital disorder of glycosylation
0.73neurodegenerative disease
0.54dengue disease
0.50congenital disorder of glycosylation
0.37COVID-19
0.37lysosomal storage disease
0.37ocular hypertension
0.32Intellectual disability
0.12hepatocellular carcinoma
0.09cervical cancer
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853)
Diseases associated with DDOST
Curated MONDO disease pages that list DDOST among their top associated genes.