DGKE

Chr 17q22

diacylglycerol kinase epsilon

Aliases:: DAGK6, DGK
MANE:: ENST00000284061.8

OMIM: 601440 ↗NCBI: 8526 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DGKE · P52429

v62025-08-01

Predicted Aligned Error matrix for DGKE — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.0/ 100

Confident

567 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)28%
Low(50–70)8%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Atypical haemolytic uraemic syndrome
BIALLELIC, autosomal or pseudoautosomal
Membranoproliferative glomerulonephritis including C3 glomerulopathy
BIALLELIC, autosomal or pseudoautosomal
Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomal
Unexplained kidney failure in young people
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunoglobulin-mediated membranoproliferative glomerulonephritis
0.79
atypical hemolytic-uremic syndrome
0.66
atypical hemolytic-uremic syndrome with DGKE deficiency
0.64
membranoproliferative glomerulonephritis
0.62
neurodegenerative disease
0.52
complement 3 glomerulopathy
0.46
hemolytic-uremic syndrome
0.45
atypical hemolytic-uremic syndrome with C3 anomaly
0.37
osteoarthritis, hip
0.31
total hip arthroplasty
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diacylglycerol kinase epsilon

Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:21477596, PubMed:22108654, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15544348, PubMed:8626589). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654)