DHX37

Chr 12q24.31

DEAH-box helicase 37

Aliases:: KIAA1517, MGC4322, MGC2695, Dhr1
MANE:: ENST00000308736.7

OMIM: 617362 ↗NCBI: 57647 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DHX37 · Q8IY37

v62025-08-01

Predicted Aligned Error matrix for DHX37 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.9/ 100

Confident

1,157 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)30%
Low(50–70)6%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Differences in sex development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

46,XY sex reversal 11
0.76
neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies
0.67
Testicular regression syndrome
0.66
neurodegenerative disease
0.50
Alzheimer disease
0.46
multiple sclerosis
0.46
lysosomal storage disease
0.46
Parkinson disease
0.46
Intellectual disability
0.39
Neurodevelopmental delay
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Probable ATP-dependent RNA helicase DHX37

ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably also plays a role in brain development (PubMed:31256877)