AlphaFold predicted structure
DHX38 · Q92620
Mean pLDDT
68.1/ 100
Low
1,227 residues
Confidence breakdown
- Very high(≥ 90)17%
- Confident(70–90)42%
- Low(50–70)12%
- Very low(< 50)29%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DHX38
Chr 16q22.2DEAH-box helicase 38
- Aliases:
- Prp16, KIAA0224, hPrp16, PRPF16
- MANE:
- ENST00000268482.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Retinal disorders
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
retinitis pigmentosa
0.61neurodegenerative disease
0.50retinitis pigmentosa 84
0.45Retinal dystrophy
0.39dengue disease
0.37coronary artery disorder
0.33hyperlipidemia
0.29autosomal recessive retinitis pigmentosa
0.26Hypercholesterolemia
0.25ovarian neoplasm
0.24
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131)