AlphaFold predicted structure
DICER1 · Q9UPY3
Mean pLDDT
67.6/ 100
Low
1,922 residues
Confidence breakdown
- Very high(≥ 90)16%
- Confident(70–90)45%
- Low(50–70)10%
- Very low(< 50)29%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DICER1
Chr 14q32.13dicer 1, ribonuclease III
- Aliases:
- Dicer, KIAA0928, K12H4.8-LIKE, HERNA
- MANE:
- ENST00000343455.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCOVID-19 research
UnknownDICER1-related cancer predisposition
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedEmbryonal tumour of possible germline origin
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited non-medullary thyroid cancer
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
+5 more panels — install the extension to see the full list inline on any page.
Disease associations (Open Targets)
DICER1-related tumor predisposition
0.83pleuropulmonary blastoma
0.76Familial multinodular goiter
0.76goiter, multinodular 1, with or without Sertoli-Leydig cell tumors
0.75global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
0.73rhabdomyosarcoma, embryonal, 2
0.69embryonal rhabdomyosarcoma
0.60pineoblastoma
0.58Inherited cancer-predisposing syndrome
0.57hereditary neoplastic syndrome
0.57
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Endoribonuclease Dicer
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes
Diseases associated with DICER1
Curated MONDO disease pages that list DICER1 among their top associated genes.