AlphaFold predicted structure
DLG2 · Q15700
Mean pLDDT
69.9/ 100
Low
870 residues
Confidence breakdown
- Very high(≥ 90)39%
- Confident(70–90)24%
- Low(50–70)3%
- Very low(< 50)33%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
DLG2
Chr 11q14.1discs large MAGUK scaffold protein 2
- Aliases:
- PSD-93, PSD93, chapsyn-110, PPP1R58
- MANE:
- ENST00000376104.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Intellectual disability
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
alcohol drinking
0.38myopia
0.33refractive error
0.32placental abruption
0.31multiple sclerosis
0.31poisoning
0.31placental retention
0.31urolithiasis
0.31cardiac arrhythmia
0.31Abnormal nasolacrimal system morphology
0.31
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Disks large homolog 2
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)
Diseases associated with DLG2
Curated MONDO disease pages that list DLG2 among their top associated genes.