DLG5

Chr 10q22.3

discs large MAGUK scaffold protein 5

Aliases:: P-dlg, KIAA0583
MANE:: ENST00000372391.7

OMIM: 604090 ↗NCBI: 9231 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DLG5 · Q8TDM6

v62025-08-01

Predicted Aligned Error matrix for DLG5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.4/ 100

Low

1,919 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)39%
Low(50–70)6%
Very low(< 50)40%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Renal ciliopathies
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

Yuksel-Vogel-Bauer syndrome
0.65
thyroid gland carcinoma
0.39
atrial fibrillation
0.33
androgenetic alopecia
0.32
metabolic dysfunction-associated steatotic liver disease
0.31
Precordial pain
0.29
alcohol drinking
0.29
bipolar disorder
0.28
neurodegenerative disease
0.24
hypertensive disorder
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Disks large homolog 5

Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity)