DMP1

Chr 4q22.1

dentin matrix acidic phosphoprotein 1

MANE:: ENST00000339673.11

OMIM: 600980 ↗NCBI: 1758 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DMP1 · Q13316

v62025-08-01

Predicted Aligned Error matrix for DMP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

47.6/ 100

Very low

513 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)3%
Low(50–70)22%
Very low(< 50)75%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hypophosphataemia or rickets
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Osteogenesis imperfecta

Disease associations (Open Targets)

autosomal recessive hypophosphatemic rickets
0.67
hypophosphatemic rickets
0.50
Dent disease
0.39
brachydactyly type A1
0.39
Acromesomelic dysplasia, Grebe type
0.39
brachydactyly type A2
0.39
brachydactyly type C
0.39
Acromesomelic dysplasia, Hunter-Thomson type
0.39
acromesomelic dysplasia 2A
0.38
acromesomelic dysplasia 2B
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclin-D-binding Myb-like transcription factor 1

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1