DNAH6

Chr 2p11.2

dynein axonemal heavy chain 6

Aliases:: Dnahc6, HL-2, FLJ37357
MANE:: ENST00000389394.8

OMIM: 603336 ↗NCBI: 1768 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DNAH6 · Q9C0G6-4isoform

No predicted structure exists for the canonical Q9C0G6 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for DNAH6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.6/ 100

Confident

2,530 residues

Confidence breakdown

Very high(≥ 90)8%
Confident(70–90)69%
Low(50–70)14%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Laterality disorders and isomerism
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

spermatogenic failure
0.40
alcohol drinking
0.39
preeclampsia
0.35
spermatocele
0.29
hypospadias
0.29
Abnormality of the integument
0.28
Alzheimer disease
0.28
Parkinson disease
0.28
multiple sclerosis
0.28
neurodegenerative disease
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dynein axonemal heavy chain 6

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity)