DNAH8

Chr 6p21.2

dynein axonemal heavy chain 8

Aliases:: hdhc9
MANE:: ENST00000327475.11

OMIM: 603337 ↗NCBI: 1769 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DNAH8 · Q96JB1

Mean pLDDT

Not published

AlphaFold has not published a prediction for this sequence. This is common for very long proteins.

Confidence breakdown

Check AlphaFold DB

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Laterality disorders and isomerism
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

spermatogenic failure 46
0.72
primary ciliary dyskinesia
0.57
diabetes mellitus
0.37
inherited obesity
0.34
pericarditis
0.31
type 1 diabetes nephropathy
0.29
ovarian neoplasm
0.26
stroke disorder
0.24
placenta praevia
0.24
Tietze syndrome
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dynein axonemal heavy chain 8

Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum (PubMed:32619401). Produces force towards the minus ends of microtubules (PubMed:32619401). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (PubMed:32619401). Involved in sperm motility; implicated in sperm flagellar assembly (PubMed:32619401)