DNAI1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Laterality disorders and isomerism

  BIALLELIC, autosomal or pseudoautosomal

• Primary ciliary disorders

  BIALLELIC, autosomal or pseudoautosomal

• Respiratory ciliopathies including non-CF bronchiectasis

  BIALLELIC, autosomal or pseudoautosomal

• Ductal plate malformation

  BIALLELIC, autosomal or pseudoautosomal

• Familial pulmonary fibrosis

• Non-CF bronchiectasis

• Paediatric disorders - additional genes

  BIALLELIC, autosomal or pseudoautosomal

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Disease associations (Open Targets)

• primary ciliary dyskinesia

  0.75

• Kartagener Syndrome

  0.70

• ciliopathy

  0.62

• bronchiectasis

  0.37

• hereditary disease

  0.34

• male infertility

  0.11

• infertility disorder

  0.11

• Congenital pulmonary alveolar proteinosis

  0.09

• Heterotaxia

  0.08

• chronic obstructive pulmonary disease

  0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with DNAI1

Curated MONDO disease pages that list DNAI1 among their top associated genes.

• ciliopathyRare