DNAJB11

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Cystic kidney disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Ductal plate malformation

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Polycystic liver disease

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Tubulointerstitial kidney disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• polycystic kidney disease 6 with or without polycystic liver disease

  0.76

• autosomal dominant polycystic kidney disease

  0.49

• hereditary disease

  0.41

• polycystic kidney disease

  0.37

• cystic kidney disease

  0.37

• dengue disease

  0.37

• familial juvenile hyperuricemic nephropathy

  0.37

• stage 5 chronic kidney disease

  0.37

• Renal cyst

  0.34

• Meckel syndrome

  0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)