DNAJC21

Chr 5p13.2

DnaJ heat shock protein family (Hsp40) member C21

Aliases:: GS3, DNAJA5, JJJ1
MANE:: ENST00000648817.1

OMIM: 617048 ↗NCBI: 134218 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DNAJC21 · Q5F1R6

v62025-08-01

Predicted Aligned Error matrix for DNAJC21 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.2/ 100

Confident

531 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)22%
Low(50–70)7%
Very low(< 50)32%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomal
Haematological malignancies cancer susceptibility
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

autosomal dominant aplasia and myelodysplasia
0.77
neurodegenerative disease
0.50
inherited bone marrow failure syndrome
0.47
Bone marrow hypocellularity
0.46
neutropenia, severe congenital, 8, autosomal dominant
0.46
Pancytopenia
0.46
Shwachman-Diamond syndrome
0.46
hereditary disease
0.41
Shwachman-Diamond syndrome 1
0.36
asthma
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DnaJ homolog subfamily C member 21

May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA