DNAJC7

Chr 17q21.2

DnaJ heat shock protein family (Hsp40) member C7

Aliases:: TPR2
MANE:: ENST00000457167.9

OMIM: 601964 ↗NCBI: 7266 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DNAJC7 · Q99615

v62025-08-01

Predicted Aligned Error matrix for DNAJC7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.3/ 100

Very high

494 residues

Confidence breakdown

Very high(≥ 90)81%
Confident(70–90)9%
Low(50–70)3%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Adult onset neurodegenerative disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

amyotrophic lateral sclerosis
0.41
Neurodevelopmental delay
0.12
epilepsy
0.12
hepatocellular carcinoma
0.08
metabolic dysfunction-associated steatotic liver disease
0.06
hypertriglyceridemia 2
0.06
Hyperlipoproteinemia type 5
0.06
hyperlipoproteinemia type V
0.06
glycogen storage disease VI
0.05
neonatal intrahepatic cholestasis due to citrin deficiency
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DnaJ homolog subfamily C member 7

Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity)