DOCK2

Chr 5q35.1

dedicator of cytokinesis 2

Aliases:: KIAA0209
MANE:: ENST00000520908.7

OMIM: 603122 ↗NCBI: 1794 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DOCK2 · Q92608

v62025-08-01

Predicted Aligned Error matrix for DOCK2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.8/ 100

Confident

1,830 residues

Confidence breakdown

Very high(≥ 90)43%
Confident(70–90)41%
Low(50–70)4%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

DOCK2 deficiency
0.79
severe combined immunodeficiency
0.37
HIV infectious disease
0.37
bipolar disorder
0.35
gestational diabetes
0.33
muscle cramp
0.31
protozoa infectious disease
0.29
inflammatory bowel disease
0.28
ulcerative colitis
0.27
placental retention
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dedicator of cytokinesis protein 2

Guanine nucleotide exchange factor (GEF) that activates monomeric GTPases by catalysing the release of bound GDP in exchange for free GTP (PubMed:32651375). Activates RAC1 and RAC2, but not CDC42 (PubMed:21613211, PubMed:32651375). Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines (PubMed:21613211). May also participate in IL2 transcriptional activation via the activation of RAC2 (PubMed:21613211)