DOCK6

Chr 19p13.2

dedicator of cytokinesis 6

Aliases:: KIAA1395, ZIR1
MANE:: ENST00000294618.12

OMIM: 614194 ↗NCBI: 57572 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DOCK6 · Q96HP0

v62025-08-01

Predicted Aligned Error matrix for DOCK6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.1/ 100

Confident

2,047 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)47%
Low(50–70)8%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Adams-Oliver syndrome
0.79
hereditary disease
0.51
bone Paget disease
0.26
hypercholanemia, familial 1
0.26
Raynaud disease
0.24
Alzheimer disease
0.21
Parkinson disease
0.21
lysosomal storage disease
0.21
neurodegenerative disease
0.21
multiple sclerosis
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dedicator of cytokinesis protein 6

Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity)