DPP9

Chr 19p13.3

dipeptidyl peptidase 9

MANE:: ENST00000262960.14

OMIM: 608258 ↗NCBI: 91039 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

DPP9 · Q86TI2

v62025-08-01

Predicted Aligned Error matrix for DPP9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.5/ 100

Very high

863 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)14%
Low(50–70)2%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hatipoglu immunodeficiency syndrome
0.62
COVID-19
0.49
neurodegenerative disease
0.40
idiopathic pulmonary fibrosis
0.39
interstitial lung disease
0.29
respiratory failure
0.26
osteoarthritis
0.26
Abnormality of the gastrointestinal tract
0.20
hepatocellular carcinoma
0.09
liver cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dipeptidyl peptidase 9

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929)