DPT

Chr 1q24.2

dermatopontin

MANE:: ENST00000367817.4

OMIM: 125597 ↗NCBI: 1805 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DPT · Q07507

v62025-08-01

Predicted Aligned Error matrix for DPT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.2/ 100

Confident

201 residues

Confidence breakdown

Very high(≥ 90)76%
Confident(70–90)4%
Low(50–70)2%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Familial Meniere Disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Sensorineural hearing impairment
0.40
hearing loss disorder
0.39
hypothyroidism
0.39
atrial fibrillation
0.35
deep vein thrombosis
0.35
Progressive sensorineural hearing impairment
0.34
COVID-19
0.34
severe acute respiratory syndrome
0.34
restless legs syndrome
0.32
septic shock
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dermatopontin

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity)