DPYSL2

Chr 8p21.2

dihydropyrimidinase like 2

Aliases:: DRP-2, DHPRP2, CRMP2, DRP2
MANE:: ENST00000521913.7

OMIM: 602463 ↗NCBI: 1808 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

DPYSL2 · Q16555

v62025-08-01

Predicted Aligned Error matrix for DPYSL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.3/ 100

Very high

572 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)5%
Low(50–70)5%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

hypertensive disorder
0.43
autosomal dominant non-syndromic intellectual disability
0.37
ovarian neoplasm
0.30
glomerulonephritis
0.29
cardiovascular disorder
0.29
hereditary disease
0.27
metabolic disease
0.26
placental abruption
0.26
Intellectual disability
0.19
Aplasia/Hypoplasia of the corpus callosum
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dihydropyrimidinase-related protein 2

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis