DRC1

Chr 2p23.3

dynein regulatory complex subunit 1

Aliases:: MGC16372, FLJ32660, CILD21
MANE:: ENST00000288710.7

OMIM: 615288 ↗NCBI: 92749 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DRC1 · Q96MC2

v62025-08-01

Predicted Aligned Error matrix for DRC1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.8/ 100

Confident

740 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)37%
Low(50–70)11%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Laterality disorders and isomerism
Rare multisystem ciliopathy disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

primary ciliary dyskinesia
0.75
primary ciliary dyskinesia 21
0.73
spermatogenic failure 80
0.52
non-syndromic male infertility due to sperm motility disorder
0.39
ciliopathy
0.38
Kartagener Syndrome
0.27
post term pregnancy
0.25
hereditary disease
0.19
atrial fibrillation
0.14
diabetes mellitus
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dynein regulatory complex protein 1

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:23354437, PubMed:34169321). Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437)