DSPP

Chr 4q22.1

dentin sialophosphoprotein

Aliases:: DMP3
MANE:: ENST00000651931.1

OMIM: 125485 ↗NCBI: 1834 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

DSPP · Q9NZW4

v62025-08-01

Predicted Aligned Error matrix for DSPP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

39.3/ 100

Very low

1,301 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)1%
Low(50–70)3%
Very low(< 50)96%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Amelogenesis imperfecta
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Osteogenesis imperfecta
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

dentinogenesis imperfecta type 2
0.78
deafness, autosomal dominant 39, with dentinogenesis imperfecta 1
0.71
dentinogenesis imperfecta type 3
0.70
dentin dysplasia type II
0.62
dentinogenesis imperfecta
0.57
Pulp calcification
0.50
hereditary disease
0.45
gout
0.40
atypical dentin dysplasia due to SMOC2 deficiency
0.39
hearing loss disorder
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dentin sialophosphoprotein

DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals